First public performance as a soloist with Percussion Ensemble of Mark Pekarsky took place in The Central House of Artist in 1982 in Moscow. 1983-1993 - collaboration with Sergey Kuryokhin (duo, combo and big band POP MECHANICS). Concerts with POP-MECHANICS and Sergey Kuryokhin - all over Soviet Union, Finland, Italy, France, Denmark. Since 1986 - collaboration with the Gypsy singer Valentina Ponomareva. Duo Ponomareva-Letov performed in USSR, Switzerland. In 1985 Sergey Letov has founded winds ensemble TRI-O and since 2002 founded Saxophone Quartet (or sometimes trio) Russian Sax Mafia. Sergey Letov is interested in various projects, contacts, new partnerships, he performed also with modern poets, writers and dancers. Since 1984 Sergey Letov plays with famous russian rock and alternative bands. In the 1988-1989 he worked in Theatre of Improvisation in Moscow, in 1990-1991 in Moscow Creative Workshops (Mikhail Mokeev), in 1989-1992 and then since 1996 in the School of Dramatic Art of Anatoly Vassiliev, in 1991-1992 in Centro Sperimentale di Teatro a Roma (Sharoo and Reza Kheradmand), in 1991-1992 with clown company "Licedei-4" in France, Taganka Theatre since 1996 - "Moscow- Petushki" (Valentin Ryzhiy) and "Marat and Marquis de Sade" (Yuriy Lyubimov), Kinetic Theatre of Sasha Pepelaev (1997-1998), Saumarkt Theater in Feldkirch, Austria in 1998 - Hochzeitsreise by Vladimir Sorokin (Andreas Marent), Moscow Art Academic Theatre (MKhT by A.P. Chekhov) - 1999-2000, Theatre "Chelovek" in Moscow - since 2001 - "Entre Nous" by Ionesco, Kharms, Valer Novarina a.o. Sergey Letov appears as Tiresias in "Antigone - Forever" by Sophocles (2008). Since 2013 Sergey Letov participates in ballet by Anna Koblova (soloist and choreographer of Bolshoi Theatre) "Phantasy on Polynesia". Since 2014 Sergey Letov paricipated in "Taganskiy Front", Theater performance at Taganka Theater. Since 2015 Sergey Letov participates in Theatre performances "1945. Peace creation - Repost" and "Sevastopol" by Vlad Malenko.
Another form of Sergey Letov' activities is composing and playing music for cinema and old silent movies.
Sergey Letov plays sopranino, soprano, tenor, baritone and C-Melody saxophones, bass clarinet, flute, piccolo and alto flute, Bashkirian kurai, Iranian ney, Akai EWI 4000s, Akai EWI 5000 and Yamaha WX-5.