Their lyrics cover a wide range of themes including death, luck, the devil, and heartbreak, and their music incorporates elements of blues, punk, grunge, psychobilly, and stoner rock. Santamuerte's influences include Robert Johnson, Nirvana, and Queens of the Stone Age. In 2015, the band released their debut album Letras de mi Muerte, which was selected as the album of the week on Radio 3 in Spain. In 2016, they had the opportunity to open for Michael Graves of the Misfits. In 2018, Santamuerte signed with the French music agency Cezamé and their music has been featured in films, TV shows, and documentaries including The NY Times. They have also played at festivals such as the Trash Blues Festival and the Umsonst und Draussen in Germany. In 2022, the band received funding from the German government to record their second album in a castle outside Dresden and their music was featured at Universal Music's Halloween Horror Nights in Orlando. In 2023, Santamuerte will release their new album META MORE FUZZ and tour Ecuador, Germany, the US, and Mexico. Radio Cocoa described the band as "defying the fear of death, [having] a deity name, and paying tribute to that lady with the attitude of a saint and the face of a skull."

"Santamuerte is a band that defies the fear of death and pays tribute to a deity with the name and attitude of a saint and the appearance of a skull"
Radio Cocoa