Since her beginnings, both Latin music and Anglophone pop have been an important part of her career. Inspired by artists such as Gloria Estefan, Celine Dion, Selena, Ednita Nazario and others, her music connects with audiences from different cultures around the world.

In 2013, her single "Angels and Demons" was part of the soundtrack of Lifetime TV's Dance Moms in its third season premiere episode, which attracted over 3 million viewers, the biggest season premiere during that time. time received thousands of digital sales on iTunes and millions of views on YouTube. Since then, it continues to draw streams on Hulu by the millions each year bringing new audiences to discover her music.

For 2014, the song "With You (Contigo)" was presented as the main theme of love for the characters Greta and Lazaro and "No Soy Un Angel" for the characters Smith and El Supremo in the telenovela Reina de Corazones on Telemundo. The telenovela was transmitted throughout the world through Telemundo International, which continued to attract new listeners daily. A fan made video saw more than 28 million streams during its broadcast in India and Indonesia from September 2017 to 2018.

The year 2023 has continued to bring much success with the radio chart topping single “Lo Que Pudo Ser” with Dominican urban artist Dany, reaching the Top 20 lists on iTunes in several countries and Top 10 on the radio including #4 on Radio Latina (Paris), the largest latin station in France as well as the rebroadcast and re-edited telenovela “Brujas” on Canal 13 in Chile with the song “Locura” on over 30 episodes as part of their main soundtrack with an average of 30 points, amassing to over 2 million viewers daily.

Melissa is also a philanthropist and has created the Stardust Foundation, which provided much-needed relief to Puerto Rico due to Hurricane Maria on September 20, 2017 by raising over 7k and helped over 150 families in her hometown and the south-west region of the island.